Knoxville, TN is located in Knox County. It is home to 45660 people. The median household income is $75,428.00 (Source: 2000 Census). The average home value was $165,100.00 (Source: 2000 Census). Nearby towns and cities include Oak Ridge, Clinton, Powell, Maryville, Sevierville. Find listings of real estate for sale in Knoxville below.